This paper was carried out to observe prostaglandin F_(2α)-induced morphological changes in the placenta.
White mice received intramuscular injections of PGF_(2α)(containing dinoprost tromethamine 0.5㎎/㎖, Upjohn Co.) in once or twice with doses of 0.1㎖ on 10th to 18th day of their respective pregnancies, the histological changes of the placentae and ovaries were observed with light microscope.
Abortion within 21 to 51 hours following PGF_(2α) administration occurred in the pregnant mice. Vacuolization of trophospongial cells, giant cells and myometrium under decidua basalis, spherical acidophilic inclusion bodies of various sixtes in trophospongial cells and giant cells. hydropic degeneration and necrosis of labyrinthine trophoblasts and yolk cells, and infltration of neutrophils in the placenta and the uterus were observed.
In addition, there were decrease in glycogen of the placental labyrinth and the visceral yolk sac, but increase in glycogen deposit of mesometrial myometrium. Atrophy and increase in number of large lipid droplets of the luteal cells and proliferation of fibroblasts were also recognized in the corpora lutea.
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